Allelic differences affecting invariant chain dependency of MHC class II subunit assembly.

Journal article

The conserved invariant chain associates with highly polymorphic alpha and beta subunits guiding class II transport through the secretory pathway. Early associations of these three polypeptides inside antigen-presenting cells are poorly understood. The present experiments provide a detailed picture of the structure and fate of class II alpha and beta subunits in invariant chain mutants possessing different MHC haplotypes. In the absence of invariant chain, A alpha bA beta b is predominantly e...

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Authors: Bikoff, E; Germain, R; Robertson, E

• Publication status: Published
• Journal: Immunity
• Volume: 2
• Issue: 3
• Pages: 301-310
• Publication date: 1995-03-01
• DOI: 10.1016/1074-7613(95)90054-3
• EISSN: 1097-4180
• ISSN: 1074-7613
• Language: English
• Keywords: B-Lymphocytes; Mice, Knockout; Precipitin Tests; Protein Conformation; Alleles; Base Sequence; Mice, Inbred C57BL; Lipopolysaccharides; Amino Acid Sequence; Histocompatibility Antigens Class II; Interleukin-4; Mice; Animals; Mice, Inbred BALB C; Molecular Sequence Data; Antigens, Differentiation, B-Lymphocyte