CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo.

Journal article

BACKGROUND AND PURPOSE: Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor inhibition has been hypothesized to provide neuroprotective efficacy after cerebral ischemia on the basis of the activity in experimental ischemia models of a variety of compounds with varying selectivity for AMPA over other glutamate receptor subtypes. CP-465,022 is a new, potent, and selective noncompetitive AMPA receptor antagonist. The present study investigated the ability of this compound t...

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Authors: Menniti, F; Buchan, A; Chenard, B; Critchett, D; Ganong, A

• Publication status: Published
• Journal: Stroke; a journal of cerebral circulation
• Volume: 34
• Issue: 1
• Pages: 171-176
• Publication date: 2003-01-01
• DOI: 10.1161/01.str.0000048216.90221.9c
• EISSN: 1524-4628
• ISSN: 0039-2499
• Language: English
• Keywords: Animals; Motor Activity; Receptors, AMPA; Seizures; Rats; Male; Synaptic Transmission; Pentylenetetrazole; Hippocampus; Neuroprotective Agents; Brain Ischemia; Quinazolines