- Abstract:
-
Melioidosis is an infectious disease with a propensity for relapse, despite prolonged antibiotic eradication therapy for 12 to 20 weeks. A pharmacokinetic (PK) simulation study was performed to determine the optimal dosing of cotrimoxazole (trimethoprim-sulfamethoxazole [TMP-SMX]) used in current eradication regimens in Thailand and Australia. Data for bioavailability, protein binding, and coefficients of absorption and elimination were taken from published literature. Apparent volumes of dis...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/aac.01301-08
-
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- Journal:
- Antimicrobial agents and chemotherapy
- Volume:
- 53
- Issue:
- 10
- Pages:
- 4193-4199
- Publication date:
- 2009-10-05
- DOI:
- EISSN:
-
1098-6596
- ISSN:
-
0066-4804
- URN:
-
uuid:e133ae9b-5300-4262-b984-1e88444c3b16
- Source identifiers:
-
23863
- Local pid:
- pubs:23863
- Copyright date:
- 2009
Journal article
Dosing regimens of cotrimoxazole (trimethoprim-sulfamethoxazole) for melioidosis.
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