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Dosing regimens of cotrimoxazole (trimethoprim-sulfamethoxazole) for melioidosis.

Abstract:

Melioidosis is an infectious disease with a propensity for relapse, despite prolonged antibiotic eradication therapy for 12 to 20 weeks. A pharmacokinetic (PK) simulation study was performed to determine the optimal dosing of cotrimoxazole (trimethoprim-sulfamethoxazole [TMP-SMX]) used in current eradication regimens in Thailand and Australia. Data for bioavailability, protein binding, and coefficients of absorption and elimination were taken from published literature. Apparent volumes of dis...

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Publication status:
Published

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Publisher copy:
10.1128/aac.01301-08

Authors


McBryde, ES More by this author
Wuthiekanun, V More by this author
Chierakul, W More by this author
Amornchai, P More by this author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
53
Issue:
10
Pages:
4193-4199
Publication date:
2009-10-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:e133ae9b-5300-4262-b984-1e88444c3b16
Source identifiers:
23863
Local pid:
pubs:23863

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