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Metabolic imbalance and prostate cancer progression.

Abstract:

There is substantial evidence implicating environmental factors in the progression of prostate cancer. The metabolic consequences of a western lifestyle, such as obesity, insulin resistance and abnormal hormone production have been linked to prostate carcinogenesis through multiple overlapping pathways. Insulin resistance results in raised levels of the mitogens insulin and insulin-like growth factor-1, both of which may affect prostate cancer directly, or through their effect on other metabo...

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Authors


Burton, AJ More by this author
Tilling, KM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences, Biomedical Research Centre
Rowlands, MA More by this author
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Journal:
International journal of molecular epidemiology and genetics
Volume:
1
Issue:
4
Pages:
248-271
Publication date:
2010
EISSN:
1948-1756
URN:
uuid:e132b5e5-6553-4b19-b7be-716c02b6f417
Source identifiers:
121048
Local pid:
pubs:121048

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