Metabolic imbalance and prostate cancer progression.

Journal article

There is substantial evidence implicating environmental factors in the progression of prostate cancer. The metabolic consequences of a western lifestyle, such as obesity, insulin resistance and abnormal hormone production have been linked to prostate carcinogenesis through multiple overlapping pathways. Insulin resistance results in raised levels of the mitogens insulin and insulin-like growth factor-1, both of which may affect prostate cancer directly, or through their effect on other metabo...

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Authors: Burton, A; Tilling, K; Holly, J; Hamdy, F; Rowlands, M

• Journal: International journal of molecular epidemiology and genetics
• Volume: 1
• Issue: 4
• Pages: 248-271
• Publication date: 2010-01-01
• EISSN: 1948-1756
• Language: English
• Keywords: metabolism; Prostate cancer; adipokines; obesity; diabetes; inflammation; insulin-like growth factors