Journal article

Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase.

Abstract:: 2-Oxoglutarate and iron dependent oxygenases have potential for the stereoselective hydroxylation of amino acids and related compounds. The biochemical and kinetic properties of recombinant γ-butyrobetaine hydroxylase from human and Pseudomonas sp. AK1 were compared. The results reveal differences between the two BBOXs, including in their stimulation by ascorbate. Despite their closely related sequences, the two enzymes also display different substrate selectivities, including for the product...
Expand abstract
Collapse abstract

Publication status:: Published

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Rydzik, A., Leung, I., Kochan, G., Loik, N., Henry, L., McDonough, M., Claridge, T., & Schofield, C. (2014). Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase. Organic and Biomolecular Chemistry, 12(33), 6354–6358.

MLA Style

Rydzik, A., et al. “Comparison of the Substrate Selectivity and Biochemical Properties of Human and Bacterial γ-Butyrobetaine Hydroxylase.” Organic and Biomolecular Chemistry, vol. 12, no. 33, Royal Society of Chemistry, 2014, pp. 6354–58.

Chicago Style

Rydzik, A, I Leung, G Kochan, N Loik, L Henry, M McDonough, T Claridge, and C Schofield. 2014. “Comparison of the Substrate Selectivity and Biochemical Properties of Human and Bacterial γ-Butyrobetaine Hydroxylase.” Organic and Biomolecular Chemistry 12 (33): 6354–58.
Tweet
Print

Access Document

Publisher copy:: 10.1039/c4ob01167h

Authors

+ Rydzik, A More by this author

Role:

Author

+ Leung, I More by this author

Role:

Author

+ Kochan, G More by this author

Role:

Author

+ Loik, N More by this author

Role:

Author

+ Henry, L More by this author

Role:

Author

More authors...

Bibliographic Details

Publisher:: Royal Society of Chemistry
Journal:: Organic and biomolecular chemistry More from this journal
Volume:: 12
Issue:: 33
Pages:: 6354-6358
Publication date:: 2014-09-01
DOI:: 10.1039/c4ob01167h
EISSN:: 1477-0539
ISSN:: 1477-0520

Item Description

Language:: English
Pubs id:: pubs:476119
UUID:: uuid:e12a9118-63de-478f-8fdd-8cb2ddb8e17a
Local pid:: pubs:476119
Source identifiers:: 476119
Deposit date:: 2014-08-13

Terms of use

Copyright date:: 2014

Licence:: Terms and Conditions of Use for Oxford University Research Archive

Metrics

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP