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Journal article

Effect of immune pressure on hepatitis C virus evolution: insights from a single-source outbreak.

Abstract:

UNLABELLED: The host's immune response to hepatitis C virus (HCV) can result in the selection of characteristic mutations (adaptations) that enable the virus to escape this response. The ability of the virus to mutate at these sites is dependent on the incoming virus, the fitness cost incurred by the mutation, and the benefit to the virus in escaping the response. Studies examining viral adaptation in chronic HCV infection have shown that these characteristic immune escape mutations can be ob...

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Publication status:
Published

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Publisher copy:
10.1002/hep.24076

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Journal:
Hepatology (Baltimore, Md.)
Volume:
53
Issue:
2
Pages:
396-405
Publication date:
2011-02-05
DOI:
EISSN:
1527-3350
ISSN:
0270-9139
URN:
uuid:e1256d93-43ad-4733-b112-7ed7aec2b022
Source identifiers:
112550
Local pid:
pubs:112550

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