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Cytosolic calcium ions exert a major influence on the firing rate and maintenance of pacemaker activity in guinea-pig sinus node.

Abstract:

The sino-atrial node (SAN) provides the electrical stimulus to initiate every heart beat. Cellular processes underlying this activity have been debated extensively, especially with regards to the role of intracellular calcium. We have used whole-cell application of 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA), a rapid calcium chelator, to guinea pig isolated SAN myocytes to assess the effect of rapid reduction of intracellular calcium on SAN cell electrical activity. High-...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fphys.2015.00023

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Publisher:
Frontiers Publisher's website
Journal:
Frontiers in physiology Journal website
Volume:
6
Issue:
FEB
Pages:
23
Publication date:
2015
DOI:
EISSN:
1664-042X
ISSN:
1664-042X
URN:
uuid:e11b4171-2792-4bd1-9f63-aa157d52ed76
Source identifiers:
509934
Local pid:
pubs:509934

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