Journal article icon

Journal article

Recombination within the human embryonic xi-globin locus: a common xi-xi chromosome produced by gene conversion of the psi xi gene.

Abstract:

The duplicated human embryonic alpha-like globin genes encode a 5' functional zeta (xi 2) gene and a highly homologous pseudogene (psi xi 1). We have identified chromosomes with a xi 2-xi 1 rather than a xi 2-psi xi 1 arrangement by genomic mapping and oligonucleotide analysis. The DNA sequence of a cloned downstream xi-like gene provides direct evidence for the conversion of a psi xi 1----xi 1 gene, by a xi 2 gene. We present data suggesting that this gene conversion, which removed the only ...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Nicholls, RD More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
Journal:
Cell
Volume:
42
Issue:
3
Pages:
809-819
Publication date:
1985-10-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:e114240a-e67d-437d-a55d-0fa188e98dc6
Source identifiers:
95425
Local pid:
pubs:95425

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP