Association of genetic mutations in Plasmodium vivax dhfr with resistance to sulfadoxine-pyrimethamine: geographical and clinical correlates.

Journal article

Mutations in the Plasmodium falciparum gene (dhfr) encoding dihydrofolate reductase are associated with resistance to antifols. Plasmodium vivax, the more prevalent malaria parasite in Asia and the Americas, is considered antifol resistant. Functional polymorphisms in the dhfr gene of P. vivax (pvdhfr) were assessed by PCR-restriction fragment length polymorphism using blood samples taken from 125 patients with acute vivax malaria from three widely separated locations, Thailand (n = 100), Ind...

Expand abstract

Authors: Imwong, M; Pukrittakayamee, S; Looareesuwan, S; Pasvol, G; Poirreiz, J

• Publication status: Published
• Journal: Antimicrobial agents and chemotherapy
• Volume: 45
• Issue: 11
• Pages: 3122-3127
• Publication date: 2001-11-01
• DOI: 10.1128/aac.45.11.3122-3127.2001
• EISSN: 1098-6596
• ISSN: 0066-4804
• Language: English
• Keywords: Adult; DNA, Bacterial; Tetrahydrofolate Dehydrogenase; Polymorphism, Restriction Fragment Length; Reverse Transcriptase Polymerase Chain Reaction; Sulfadoxine; Antimalarials; Drug Combinations; Mutation; Templates, Genetic; Pyrimethamine; Humans; Drug Resistance; Animals; Plasmodium vivax