Role of type-1 11beta-hydroxysteroid dehydrogenase in detoxification processes.

Journal article

Carbonyl reduction is a significant step in the biotransformation leading to the elimination, of endogenous and exogenous aldehydes, ketones and quinones. This reaction is mediated by members of the aldo-keto reductase and short-chain dehydrogenase/reductase (SDR) superfamilies. The essential role of these enzymes in protecting organisms from damage by the accumulation of toxic carbonyl compounds is generally accepted, although their physiological roles are not always clear. Recently, the SDR...

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Authors: Maser, E; Oppermann, U

• Journal: European journal of biochemistry / FEBS
• Volume: 249
• Issue: 2
• Pages: 365-369
• Publication date: 1997-10-01
• DOI: 10.1111/j.1432-1033.1997.00365.x
• EISSN: 1432-1033
• ISSN: 0014-2956
• Language: English
• Keywords: Xenobiotics; Animals; 11-beta-Hydroxysteroid Dehydrogenases; Hydroxysteroid Dehydrogenases; Liver; Nitrosamines; Humans; Insecticides; Metabolic Detoxication, Drug; Carcinogens; Microsomes