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Reinnervation of the denervated striatum by substantia nigra transplants: functional consequences as revealed by pharmacological and sensorimotor testing.

Abstract:

Embryonic substantia nigra (SN) was transplanted to the neostriatum in adult rats subjected to a unilateral or serial bilateral destruction of the nigrostriatal dopamine (DA) pathway. The survival of the graft and the growth of DA-containing fibers from the graft into the host brain was studied by fluorescence histochemistry and micro-fluorometry. The motor asymmetry, and the contralateral 'sensory neglect' induced by a unilateral destruction of the nigrostriatal DA pathway, were monitored in...

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Publication status:
Published

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Authors


Björklund, A More by this author
Dunnett, SB More by this author
Stenevi, U More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
Brain research
Volume:
199
Issue:
2
Pages:
307-333
Publication date:
1980-10-05
DOI:
EISSN:
1872-6240
ISSN:
0006-8993
URN:
uuid:e0ff4f82-1cc0-4b60-b279-73daee49ae74
Source identifiers:
5729
Local pid:
pubs:5729

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