Blast-1 possesses a glycosyl-phosphatidylinositol (GPI) membrane anchor, is related to LFA-3 and OX-45, and maps to chromosome 1q21-23.

Journal article

Blast-1 is a human activation-associated glycoprotein expressed on the surface of leukocytes. Analysis of a translated sequence from a Blast-1 cDNA reveals a single hydrophobic sequence which could traverse the plasma membrane, but is devoid of charged residues that might represent a cytoplasmic tail. Consistent with this characteristic, Blast-1 is demonstrated here to be anchored to the cell surface through a glycosyl-phosphatidylinositol (GPI)-containing lipid. Comparison of Blast-1 to othe...

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Authors: Staunton, D; Fisher, R; LeBeau, M; Lawrence, J; Barton, D

• Journal: Journal of experimental medicine
• Volume: 169
• Issue: 3
• Pages: 1087-1099
• Publication date: 1989-03-01
• DOI: 10.1084/jem.169.3.1087
• EISSN: 1540-9538
• ISSN: 0022-1007
• Language: English
• Keywords: Phosphatidylinositols; Sequence Homology, Nucleic Acid; Nucleic Acid Hybridization; Molecular Sequence Data; Cell Line, Transformed; Glycolipids; Chromosome Mapping; Antigens, CD; Type C Phospholipases; Chromosomes, Human, Pair 1; Glycosylphosphatidylinositols; Protein Conformation; Antigens, CD58; Antigens, Surface; Glycosylation; Phytohemagglutinins; Lymphocyte Activation; Humans; Amino Acid Sequence; T-Lymphocytes; Membrane Glycoproteins; Animals; Cricetinae