The activation of endothelin-1 pathway during methionine-induced homocysteinemia mediates endothelial dysfunction in hypertensive individuals.

Journal article

OBJECTIVES: Endothelin-1 (ET-1) is a key regulator of arterial blood pressure in humans, and homocysteinemia is associated with increased oxidative stress. It is still unclear whether homocysteine-induced oxidative stress is implicated in the regulation of ET-1 expression. We examined the impact of acute homocysteinemia on endothelial function in hypertensive patients and healthy individuals, and the potential role of ET-1. METHODS: In this double-blind, placebo-controlled study, 39 hyperten...

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Authors: Tousoulis, D; Bouras, G; Antoniades, C; Marinou, K; Miliou, A

• Journal: Journal of hypertension
• Volume: 28
• Issue: 5
• Pages: 925-930
• Publication date: 2010-05-01
• DOI: 10.1097/hjh.0b013e32833778b2
• EISSN: 1473-5598
• ISSN: 0263-6352
• Language: English
• Keywords: Hypertension; Signal Transduction; Homocysteine; Humans; Vasodilation; Adult; Methionine; Female; Hyperhomocysteinemia; Male; Ascorbic Acid; Oxidative Stress; Vitamin E; Endothelin-1; Double-Blind Method; Endothelium, Vascular