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Journal article

Structural basis for recognition and repair of the 3′-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis

Abstract:

NExo is an enzyme from Neisseria meningitidis that is specialized in the removal of the 3′-phosphate and other 3′-lesions, which are potential blocks for DNA repair. NExo is a highly active DNA 3′-phosphatase, and although it is from the class II AP family it lacks AP endonuclease activity. In contrast, the NExo homologue NApe, lacks 3′-phosphatase activity but is an efficient AP endonuclease. These enzymes act together to protect the meningococcus from DNA damage arising mainly from oxidativ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/nar/gky934

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Funding agency for:
Tang, CM
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
46
Issue:
22
Pages:
11980–11989
Publication date:
2018-10-17
Acceptance date:
2018-09-19
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pubs id:
pubs:929158
URN:
uri:e0cd39f0-e5d5-4f21-9093-08fbb9690d05
UUID:
uuid:e0cd39f0-e5d5-4f21-9093-08fbb9690d05
Local pid:
pubs:929158

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