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Modeling interactions with known risk loci-a Bayesian model averaging approach.

Abstract:

Genome-wide association studies (GWAS) are now clearly established as a powerful method for detecting loci involved in the etiology of common complex diseases. Most diseases and traits studied using the GWAS approach now have several loci that have been shown to be convincingly replicated. It is generally the case that these loci have been identified using single locus association scans of genotyped or imputed SNPs and very few loci have been identified by taking interactions into account. We...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics, Clinical Medicine
Role:
Author
Journal:
Annals of human genetics
Volume:
75
Issue:
1
Pages:
1-9
Publication date:
2011-01-05
DOI:
EISSN:
1469-1809
ISSN:
0003-4800
URN:
uuid:e0c7f8cf-2ab7-4d54-8837-e4d8132ed2ca
Source identifiers:
103615
Local pid:
pubs:103615

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