IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis. (Nature cell biology, 2008)

(untitled) - Gyrd-Hansen, M; Darding, M; Miasari, M; Santoro, M; Zender, L; Xue, W; Tenev, T; da Fonseca, P; Zvelebil, M; Bujnicki, J; Lowe, S; Silke, J; et al.