IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis.

Journal article

The covalent attachment of ubiquitin to target proteins influences various cellular processes, including DNA repair, NF-kappaB signalling and cell survival. The most common mode of regulation by ubiquitin-conjugation involves specialized ubiquitin-binding proteins that bind to ubiquitylated proteins and link them to downstream biochemical processes. Unravelling how the ubiquitin-message is recognized is essential because aberrant ubiquitin-mediated signalling contributes to tumour formation. ...

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Authors: Gyrd-Hansen, M; Darding, M; Miasari, M; Santoro, M; Zender, L

• Journal: Nature cell biology
• Volume: 10
• Issue: 11
• Pages: 1309-1317
• Publication date: 2008-11-01
• DOI: 10.1038/ncb1789
• EISSN: 1476-4679
• ISSN: 1465-7392
• Language: English
• Keywords: Cell Line; Carcinoma; Inhibitor of Apoptosis Proteins; NF-kappa B; Tumor Necrosis Factor-alpha; Humans; Protein Binding; Neoplasms; Liver Neoplasms; Ubiquitin; Apoptosis; Transfection; Cell Survival; Protein Structure, Tertiary; Recombinant Fusion Proteins; Glutathione Transferase; Kidney; Plasmids; Genes, Reporter; Luciferases