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Thesis

Regulation of E2F-1 by methylation and NEDDylation

Abstract:

E2F-1 has a central role in cell cycle orchestration, and its activity is tightly regulated. One of the ways E2F-1 activity is controlled is by direct modification by post translational modifications such as acetylation, ubiquitination and phosphorylation. Here it was demonstrated that E2F-1 is targeted by two novel modifications, namely methylation by Set7/9 and NEDDylation, both within the DNA binding and heterodimerisation domain of the protein. NEDDylation and methylation of E2F-1 both...

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Institution:
University of Oxford
Research group:
Laboratory of Cancer Biology
Oxford college:
St Hilda's College
Department:
Medical Sciences Division - Clinical Pharmacology
Role:
Author

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Role:
Supervisor
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Funding agency for:
Sarah Jane Loftus
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:e0befc5a-76a3-4a35-b768-80a9dda6f307
Local pid:
ora:7606

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