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Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity.

Abstract:

OBJECTIVE: Alterations in joint mechanics can cause osteoarthritis, which results in degeneration of both cartilage and bone tissue. The objective of this work is to measure changes in the laxity of the mouse knee joint after destabilisation of the medial meniscus (DMM) and to visualise and quantify the resulting three-dimensional changes in the bone and cartilage. METHODS: Skeletally mature C57Bl6 male mice underwent DMM surgery in the right leg. Animals were sacrificed immediately 0 weeks ...

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Publication status:
Published

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Publisher copy:
10.1016/j.joca.2010.11.006

Authors


Moodie, JP More by this author
Müller, R More by this author
Vincent, TL More by this author
Shefelbine, SJ More by this author
Journal:
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
Volume:
19
Issue:
2
Pages:
163-170
Publication date:
2011-02-05
DOI:
EISSN:
1522-9653
ISSN:
1063-4584
URN:
uuid:e0b5723f-1ce4-4067-afab-17901a78361b
Source identifiers:
228438
Local pid:
pubs:228438

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