Interaction of human valve interstitial cells with collagen matrices manufactured using rapid prototyping.

Journal article

Rapid prototyping is a novel process for the production of scaffolds of predetermined size and three-dimensional shape. The aim of the study was to determine the feasibility of this technology for producing scaffolds for tissue engineering an aortic valve and the optimal concentration of collagen processed in this manner that would maintain viability and promote proliferation of human valve interstitial cells. Scaffolds of 1%, 2% and 5% w/v bovine type-I collagen were manufactured using rapid...

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Authors: Taylor, P; Sachlos, E; Dreger, SA; Chester, A; Czernuszka, J

• Publication status: Published
• Journal: Biomaterials
• Volume: 27
• Issue: 13
• Pages: 2733-2737
• Publication date: 2006-05-01
• DOI: 10.1016/j.biomaterials.2005.12.003
• EISSN: 1878-5905
• ISSN: 0142-9612
• Language: English
• Keywords: Animals; Tissue Engineering; Bioprosthesis; Aortic Valve; Collagen Type I; Apoptosis; Biocompatible Materials; Cell Survival; Manufactured Materials; Pilot Projects; Heart Valve Prosthesis; Cattle; Cells, Cultured; Cell Proliferation; Cell Culture Techniques; Myocytes, Cardiac; Materials Testing