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Human immunodeficiency virus type 1- and cytomegalovirus-specific cytotoxic T lymphocytes can persist at high frequency for prolonged periods in the absence of circulating peripheral CD4(+) T cells.

Abstract:

CD4(+) T cells are thought to be critical in the maintenance of virus-specific CD8(+) cytotoxic T-cell (CTL) responses. In human immunodeficiency virus type 1 (HIV-1) infection, a selective decline in HIV-1-specific CTL as the CD4(+) T-cell count decreases has been reported. Using HLA-peptide tetrameric complexes, we show the presence at high frequency of HIV-1- and cytomegalovirus-specific CD8(+) T cells when the peripheral CD4(+) T-cell count was low or zero in three HIV-1-infected patients...

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Publication status:
Published

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Journal:
Journal of virology
Volume:
74
Issue:
2
Pages:
1018-1022
Publication date:
2000-01-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:e0a4a7c1-f555-4b19-a530-206e3fb748fe
Source identifiers:
6727
Local pid:
pubs:6727

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