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Therapeutic administration of broadly neutralizing FI6 antibody reveals lack of interaction between human IgG1 and Pig Fc receptors

Abstract:

Influenza virus infection is a significant global health threat. Because of the lack of cross-protective universal vaccines, short time window during which antivirals are effective and drug resistance, new therapeutic anti-influenza strategies are required. Broadly, cross-protective antibodies that target conserved sites in the hemagglutinin (HA) stem region have been proposed as therapeutic agents. FI6 is the first proven such monoclonal antibody to bind to H1-H16 and is protective in mice a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fimmu.2018.00865

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Hemmink, JD More by this author
Salguero, FJ More by this author
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ORCID:
0000-0003-2057-1831
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
9
Issue:
APR
Pages:
865
Publication date:
2018-04-24
Acceptance date:
2018-04-09
DOI:
ISSN:
1664-3224
Pubs id:
pubs:846334
URN:
uri:e09ef79e-0372-4ece-82d5-ae38352c07cd
UUID:
uuid:e09ef79e-0372-4ece-82d5-ae38352c07cd
Local pid:
pubs:846334

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