Journal article : Review
Towards new TB vaccines
- Abstract:
- Mycobacterium tuberculosis remains the leading cause of death attributed to a single infectious organism. Bacillus Calmette-Guerin (BCG), the standard vaccine against M. tuberculosis, is thought to prevent only 5% of all vaccine-preventable deaths due to tuberculosis, thus an alternative vaccine is required. One of the principal barriers to vaccine development against M. tuberculosis is the complexity of the immune response to infection, with uncertainty as to what constitutes an immunological correlate of protection. In this paper, we seek to give an overview of the immunology of M. tuberculosis infection, and by doing so, investigate possible targets of vaccine development. This encompasses the innate, adaptive, mucosal and humoral immune systems. Though MVA85A did not improve protection compared with BCG alone in a large-scale clinical trial, the correlates of protection this has revealed, in addition to promising results from candidate such as VPM1002, M72/ASO1E and H56:IC31 point to a brighter future in the field of TB vaccine development.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 775.0KB, Terms of use)
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- Publisher copy:
- 10.1007/s00281-020-00794-0
Authors
- Publisher:
- Springer
- Journal:
- Seminars in Immunopathology More from this journal
- Volume:
- 42
- Issue:
- 3
- Pages:
- 315-331
- Publication date:
- 2020-03-18
- Acceptance date:
- 2020-02-27
- DOI:
- EISSN:
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1863-2300
- ISSN:
-
1863-2297
- Pmid:
-
32189035
Terms of use
- Copyright holder:
- B Brazier and H McShane
- Copyright date:
- 2020
- Rights statement:
- © The Author(s) 2020. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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