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Journal article

PTPRC (CD45) variation and disease association studied using single nucleotide polymorphism tagging.

Abstract:

CD45 is a haemopoietic tyrosine phosphatase, crucial for lymphocyte signalling. Two polymorphisms (C77G and A138G), which alter CD45 isoform expression, are associated with autoimmune and infectious diseases. Using HapMap data, we show that there is substantial linkage disequilibrium across the CD45 gene (PTPRC), with similar patterns in different populations. Employing a set of single nucleotide polymorphisms, correlated with a substantial proportion of variation across this gene, we tested ...

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Publication status:
Published

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Authors


Hennig, BJ More by this author
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Journal:
Tissue antigens
Volume:
71
Issue:
5
Pages:
458-463
Publication date:
2008-05-05
DOI:
EISSN:
1399-0039
ISSN:
0001-2815
URN:
uuid:e08f5efb-5048-4bbe-ad1e-4f55bf8ada23
Source identifiers:
34153
Local pid:
pubs:34153

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