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Calcium-calmodulin does not alter the anion permeability of the mouse TMEM16A calcium-activated chloride channel

Abstract:

The transmembrane protein TMEM16A forms a Ca2+-activated Cl− channel that is permeable to many anions, including SCN−, I−, Br−, Cl−, and HCO3−, and has been implicated in various physiological functions. Indeed, controlling anion permeation through the TMEM16A channel pore may be critical in regulating the pH of exocrine fluids such as the pancreatic juice. The anion permeability of the TMEM16A channel pore has recently been reported to be modulated by Ca2+-calmodulin (CaCaM), such that the p...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1085/jgp.201411179

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Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Population Health, Cancer Epidemiology Unit
Role:
Author
Publisher:
Rockefeller University Press Publisher's website
Journal:
The Journal of General Physiology Journal website
Volume:
144
Issue:
1
Pages:
115-124
Publication date:
2014-06-05
DOI:
EISSN:
1540-7748
ISSN:
0022-1295
URN:
uuid:e08ecd01-4787-435b-946b-adb096e2abe7
Source identifiers:
579185
Local pid:
pubs:579185

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