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Type II regulatory subunits of cAMP-dependent protein kinase and their binding proteins in the nervous system of Aplysia californica.

Abstract:

Two type II regulatory (R) subunits of cAMP-dependent protein kinase (PKA) of 50 and 47 kDa have been identified in Aplysia neurons by several criteria which include phosphorylation by the catalytic subunit of PKA and nanomolar affinity for a peptide fragment of the human thyroid protein Ht 31, properties that in mammals distinguish type II from type I R subunits. The neuronal type II R subunits are differentially localized within cells. For example, the 50-kDa polypeptide is enriched in taxo...

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Publication status:
Published

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Journal:
The Journal of biological chemistry
Volume:
269
Issue:
4
Pages:
2911-2920
Publication date:
1994-01-05
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:e07f7b74-c61a-4409-8e24-31993a270176
Source identifiers:
52278
Local pid:
pubs:52278

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