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Journal article

FOXP2 is not a major susceptibility gene for autism or specific language impairment.

Abstract:

The FOXP2 gene, located on human 7q31 (at the SPCH1 locus), encodes a transcription factor containing a polyglutamine tract and a forkhead domain. FOXP2 is mutated in a severe monogenic form of speech and language impairment, segregating within a single large pedigree, and is also disrupted by a translocation in an isolated case. Several studies of autistic disorder have demonstrated linkage to a similar region of 7q (the AUTS1 locus), leading to the proposal that a single genetic factor on 7...

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Publication status:
Published

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Publisher copy:
10.1086/339931

Authors


Newbury, DF More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
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Journal:
American journal of human genetics
Volume:
70
Issue:
5
Pages:
1318-1327
Publication date:
2002-05-05
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:e074daca-a098-4a07-af99-722163cd26e2
Source identifiers:
32072
Local pid:
pubs:32072

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