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Available carbon source influences the resistance of Neisseria meningitidis against complement.

Abstract:

Neisseria meningitidis is an important cause of septicaemia and meningitis. To cause disease, the bacterium must acquire essential nutrients for replication in the systemic circulation, while avoiding exclusion by host innate immunity. Here we show that the utilization of carbon sources by N. meningitidis determines its ability to withstand complement-mediated lysis, through the intimate relationship between metabolism and virulence in the bacterium. The gene encoding the lactate permease, lc...

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Publisher copy:
10.1084/jem.20041548

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Journal:
The Journal of experimental medicine
Volume:
201
Issue:
10
Pages:
1637-1645
Publication date:
2005-05-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:e06d9a0a-f684-4392-9e2d-d36dcae20ba6
Source identifiers:
249499
Local pid:
pubs:249499

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