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Two-way signalling through the LFA-1 lymphocyte adhesion receptor.

Abstract:

T lymphocyte recognition of foreign antigens and migration throughout the body require the regulated adhesion of lymphocytes to diverse types of cells and to the extracellular matrix. The lymphocyte adhesion 'receptor' LFA-1, a member of the integrin family, interacts with ICAM-1 and other counter-receptors to mediate adhesion. The LFA-1/ICAM-1 interaction is regulated by signals transmitted from the cytoplasm to the extracellular space. Conversely, LFA-1 transmits signals from the extracellu...

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Publisher copy:
10.1002/bies.950120905

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
BioEssays : news and reviews in molecular, cellular and developmental biology
Volume:
12
Issue:
9
Pages:
421-427
Publication date:
1990-09-05
DOI:
EISSN:
1521-1878
ISSN:
0265-9247
URN:
uuid:e06cae95-523c-4cd2-95be-a02c4a20bf04
Source identifiers:
482702
Local pid:
pubs:482702

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