Two-way signalling through the LFA-1 lymphocyte adhesion receptor.

Journal article

Abstract:: T lymphocyte recognition of foreign antigens and migration throughout the body require the regulated adhesion of lymphocytes to diverse types of cells and to the extracellular matrix. The lymphocyte adhesion 'receptor' LFA-1, a member of the integrin family, interacts with ICAM-1 and other counter-receptors to mediate adhesion. The LFA-1/ICAM-1 interaction is regulated by signals transmitted from the cytoplasm to the extracellular space. Conversely, LFA-1 transmits signals from the extracellu...
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Institution:

University of Oxford

Division:

MSD

Department:

NDORMS

Role:

Author

Journal:: BioEssays : news and reviews in molecular, cellular and developmental biology More from this journal
Volume:: 12
Issue:: 9
Pages:: 421-427
Publication date:: 1990-09-01
DOI:: 10.1002/bies.950120905
EISSN:: 1521-1878
ISSN:: 0265-9247

Language:: English
Keywords:: T-Lymphocytes

Receptors, Antigen, T-Cell

Signal Transduction

Cell Adhesion

Cell Adhesion Molecules

Models, Biological

Extracellular Matrix

Cell Movement

Lymphocyte Function-Associated Antigen-1

Integrins

Antigens

Humans
Pubs id:: pubs:482702
UUID:: uuid:e06cae95-523c-4cd2-95be-a02c4a20bf04
Local pid:: pubs:482702
Source identifiers:: 482702
Deposit date:: 2014-09-14

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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