Journal article icon

Journal article

Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells

Abstract:

During disease progression to AIDS, HIV-1 infected individuals become increasingly immunosuppressed and susceptible to opportunistic infections. It has also been demonstrated that multiple subsets of dendritic cells (DC), including DC-SIGN(+) cells, become significantly depleted in the blood and lymphoid tissues of AIDS patients, which may contribute to the failure in initiating effective host immune responses. The mechanism for DC depletion, however, is unclear. It is known that vast quantit...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.ppat.1003100

Authors


Hwang, S-L More by this author
Chung, NPY More by this author
Expand authors...

Contributors

Role:
Editor
Hong Kong, China's Special Administrative Regions More from this funder
Expand funders...
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
9
Issue:
1
Pages:
e1003100
Publication date:
2013
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:e059ecca-7cc2-4b6b-becd-f2d346382229
Source identifiers:
376254
Local pid:
pubs:376254

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP