Degradation of fibronectin in association with vascular endothelial disruption in preeclampsia.

Journal article

The objectives of this study were (1) To assess human umbilical cord vein endothelial cell (HUVEC) fibronectin (Fn) content and integrity in patients with preeclampsia and (2) to investigate the ability of Fn and Fn fragments (FnDP) to disrupt endothelial cell attachment to an Fn matrix through modulation of plasminogen activator activity. Intact Fn was released from normal cord veins, while Fn and FnDP (70 and 21 kd) were released from cord veins in culture from patients with severe preeclam...

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Authors: de Jager, C; Shephard, E; Robson, S; Jaskiewicz, K; Froese, S

• Journal: Journal of laboratory and clinical medicine
• Volume: 125
• Issue: 4
• Pages: 522-530
• Publication date: 1995-04-01
• EISSN: 1532-6543
• ISSN: 0022-2143
• Language: English
• Keywords: Electrophoresis, Polyacrylamide Gel; Plasmin; Endothelium, Vascular; Blotting, Western; Pre-Eclampsia; Pregnancy; Humans; Fibronectins; Adult; Female; Cells, Cultured; Urokinase-Type Plasminogen Activator; Microscopy, Phase-Contrast