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Degradation of fibronectin in association with vascular endothelial disruption in preeclampsia.

Abstract:

The objectives of this study were (1) To assess human umbilical cord vein endothelial cell (HUVEC) fibronectin (Fn) content and integrity in patients with preeclampsia and (2) to investigate the ability of Fn and Fn fragments (FnDP) to disrupt endothelial cell attachment to an Fn matrix through modulation of plasminogen activator activity. Intact Fn was released from normal cord veins, while Fn and FnDP (70 and 21 kd) were released from cord veins in culture from patients with severe preeclam...

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Authors


de Jager, CA More by this author
Shephard, EG More by this author
Robson, SC More by this author
Jaskiewicz, K More by this author
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Journal:
The Journal of laboratory and clinical medicine
Volume:
125
Issue:
4
Pages:
522-530
Publication date:
1995-04-05
EISSN:
1532-6543
ISSN:
0022-2143
URN:
uuid:e0560871-80ab-4244-9b2c-b4083667baab
Source identifiers:
140043
Local pid:
pubs:140043

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