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Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation.

Abstract:

Myeloablative conditioning before bone marrow transplantation (BMT) results in thymic epithelial cell (TEC) injury, T-cell immune deficiency, and susceptibility to opportunistic infections. Conditioning regimen-induced TEC damage directly contributes to slow thymopoietic recovery after BMT. Keratinocyte growth factor (KGF) is a TEC mitogen that stimulates proliferation and, when given before conditioning, reduces TEC injury. Some TEC subsets are refractory to KGF and functional T-cell respons...

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Publication status:
Published

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Journal:
Blood
Volume:
115
Issue:
5
Pages:
1088-1097
Publication date:
2010-02-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:e050843f-733a-4028-9ccb-977802b5ebe7
Source identifiers:
309048
Local pid:
pubs:309048

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