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Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo.

Abstract:

OBJECTIVE: Mechanical joint loading is critical for the development of osteoarthritis (OA). Although once regarded as a disease of cartilage attrition, OA is now known to be controlled by the expression and activity of key proteases, such as ADAMTS-5, that drive matrix degradation. This study was undertaken to investigate the link between protease expression and mechanical joint loading in vivo. METHODS: We performed a microarray analysis of genes expressed in the whole joint following surgi...

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Publication status:
Published

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Publisher copy:
10.1002/art.34420

Authors


Burleigh, A More by this author
Chanalaris, A More by this author
Gardiner, MD More by this author
Driscoll, C More by this author
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Journal:
Arthritis and rheumatism
Volume:
64
Issue:
7
Pages:
2278-2288
Publication date:
2012-07-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:e04e98c2-3845-423d-8b06-7a6a278ab2dd
Source identifiers:
249337
Local pid:
pubs:249337

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