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Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara.

Abstract:

Immunization with irradiated sporozoites can protect against malaria infection and intensive efforts are aimed at reproducing this effect with subunit vaccines. A particular sequence of subunit immunization with pre-erythrocytic antigens of Plasmodium berghei, consisting of single dose priming with plasmid DNA followed by a single boost with a recombinant modified vaccinia virus Ankara (MVA) expressing the same antigen, induced unprecedented complete protection against P. berghei sporozoite c...

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Publication status:
Published

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Publisher copy:
10.1038/nm0498-397

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
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Journal:
Nature medicine
Volume:
4
Issue:
4
Pages:
397-402
Publication date:
1998-04-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:e04d11f8-79ba-4936-bf92-d3589d7682a3
Source identifiers:
36172
Local pid:
pubs:36172

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