- Abstract:
-
AIMS: BNIP3 is a pro-apoptotic mitochondrial protein induced under hypoxic stress, with the BNIP3 gene being under direct regulation of the hypoxia-inducible HIF-1alpha transcription factor. Induction of BNIP3 leads to caspase-independent necrosis-like cell death and an aggressive tumour phenotype. The role of BNIP3 in endometrial cancer was examined. METHODS: The immunohistochemical patterns of BNIP3 expression in 72 early endometrial adenocarcinomas of the endometrioid cell type were studie...
Expand abstract - Publication status:
- Published
- Journal:
- Journal of clinical pathology
- Volume:
- 61
- Issue:
- 2
- Pages:
- 217-220
- Publication date:
- 2008-02-05
- DOI:
- EISSN:
-
1472-4146
- ISSN:
-
0021-9746
- URN:
-
uuid:e0420920-f65a-433e-94d3-b2e011065d4f
- Source identifiers:
-
119026
- Local pid:
- pubs:119026
- Copyright date:
- 2008
Journal article
BNIP3 expression in endometrial cancer relates to active hypoxia inducible factor 1alpha pathway and prognosis.
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