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BNIP3 expression in endometrial cancer relates to active hypoxia inducible factor 1alpha pathway and prognosis.

Abstract:

AIMS: BNIP3 is a pro-apoptotic mitochondrial protein induced under hypoxic stress, with the BNIP3 gene being under direct regulation of the hypoxia-inducible HIF-1alpha transcription factor. Induction of BNIP3 leads to caspase-independent necrosis-like cell death and an aggressive tumour phenotype. The role of BNIP3 in endometrial cancer was examined. METHODS: The immunohistochemical patterns of BNIP3 expression in 72 early endometrial adenocarcinomas of the endometrioid cell type were studie...

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Publication status:
Published

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Publisher copy:
10.1136/jcp.2007.046680

Authors


Giatromanolaki, A More by this author
Koukourakis, MI More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences, Biomedical Research Centre
Harris, AL More by this author
Sivridis, E More by this author
Journal:
Journal of clinical pathology
Volume:
61
Issue:
2
Pages:
217-220
Publication date:
2008-02-05
DOI:
EISSN:
1472-4146
ISSN:
0021-9746
URN:
uuid:e0420920-f65a-433e-94d3-b2e011065d4f
Source identifiers:
119026
Local pid:
pubs:119026

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