Differential contribution of dermal resident and bone marrow-derived cells to collagen production during wound healing and fibrogenesis in mice.

Journal article

Recent studies show that bone marrow (BM)-derived cells migrating into a dermal wound promote healing by producing collagen type I. However, their contribution to the repair process has not been fully verified yet. It is also unclear whether BM-derived cells participate in dermal fibrogenesis. We have addressed these issues using transgenic mice that harbor tissue-specific enhancer/promoter sequences of α2(I) collagen gene linked to either enhanced green fluorescent protein (COL/EGFP) or the ...

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Authors: Higashiyama, R; Nakao, S; Shibusawa, Y; Ishikawa, O; Moro, T

• Publication status: Published
• Journal: Journal of investigative dermatology
• Volume: 131
• Issue: 2
• Pages: 529-536
• Publication date: 2011-02-01
• DOI: 10.1038/jid.2010.314
• EISSN: 1523-1747
• ISSN: 0022-202X
• Language: English
• Keywords: Models, Animal; Cell Movement; Mice; Fibrosis; Promoter Regions, Genetic; Bone Marrow Cells; Collagen; Bone Marrow Transplantation; Mice, Inbred C57BL; Wound Healing; Green Fluorescent Proteins; Collagen Type I; Mice, Transgenic; Animals; Dermis