Journal article
Tenascin-C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression
- Abstract:
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Immune checkpoint therapy, where CD8 tumor infiltrating T lymphocytes (TIL) are reactivated, is a promising anti-cancer treatment approach, yet with low response rates. The extracellular matrix, in particular tenascin-C, may generate barriers for TIL. To investigate this possibility, we used a MMTV-NeuNT and syngeneic mammary gland grafting model derived thereof with engineered tenascin-C levels, and observed accumulation of CD8 TIL in tenascin-C-rich stroma. Inhibition studies revealed that ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 11.8MB, Terms of use)
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- Publisher copy:
- 10.15252/emmm.202013270
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Funding
Bibliographic Details
- Publisher:
- Wiley Open Access
- Journal:
- EMBO Molecular Medicine More from this journal
- Volume:
- 13
- Issue:
- 6
- Article number:
- e13270
- Publication date:
- 2021-05-14
- Acceptance date:
- 2021-04-12
- DOI:
- EISSN:
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1757-4684
- ISSN:
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1757-4676
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1171124
- Local pid:
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pubs:1171124
- Deposit date:
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2021-04-13
Terms of use
- Copyright holder:
- Murdamoothoo et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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