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Inhibitory potency of tacrolimus ointment on skin tumor induction in a mouse model of an initiation-promotion skin tumor.

Abstract:

Tacrolimus is a macrolide immunosuppressive agent, and tacrolimus ointment has been used as therapy for atopic dermatitis worldwide. Given that the immunosuppressive action of tacrolimus raises at least the theoretical potential for an increased risk of skin cancer, accurate assessment of the risk of developing skin cancer by tacrolimus ointment is necessary. The objective of the present study is to investigate the skin tumorigenic potential of commercially available tacrolimus ointment. We c...

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
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Journal:
The Journal of dermatology
Volume:
38
Issue:
6
Pages:
562-570
Publication date:
2011-06-05
DOI:
EISSN:
1346-8138
ISSN:
0385-2407
URN:
uuid:e02fe2d9-7952-429c-b046-915ae098fa0c
Source identifiers:
365872
Local pid:
pubs:365872

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