Journal article
Epitope spreading in animal models: array of hope in rheumatoid arthritis and multiple sclerosis.
- Abstract:
-
The paradigm for pathogenic autoimmunity is the generation of high-titre, affinity-matured autoantibodies to a restricted family of autoantigens, in the appropriate genetic context. Genetic determinants of autoimmunity are largely found within the major histocompatibility complex (MHC) and the 'genotype to serotype to phenotype' concept is supported in a number of autoimmune diseases, where both genotype and serotype are well established. The serotype is autoantigen-driven, with evidence of e...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Arthritis research and therapy More from this journal
- Volume:
- 10
- Issue:
- 6
- Pages:
- 122
- Publication date:
- 2008-01-01
- DOI:
- EISSN:
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1478-6362
- ISSN:
-
1478-6354
Item Description
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:244858
- UUID:
-
uuid:e01ee9c6-13d7-48c0-af7f-70b1a4dd913e
- Local pid:
-
pubs:244858
- Source identifiers:
-
244858
- Deposit date:
-
2013-11-16
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- Copyright date:
- 2008
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