SOAP, a novel malaria ookinete protein involved in mosquito midgut invasion and oocyst development.

Journal article

An essential, but poorly understood part of malaria transmission by mosquitoes is the development of the ookinetes into the sporozoite-producing oocysts on the mosquito midgut wall. For successful oocyst formation newly formed ookinetes in the midgut lumen must enter, traverse, and exit the midgut epithelium to reach the midgut basal lamina, processes collectively known as midgut invasion. After invasion ookinete-to-oocyst transition must occur, a process believed to require ookinete interact...

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Authors: Dessens, J; Sidén-Kiamos, I; Mendoza, J; Mahairaki, V; Khater, E

• Journal: Molecular microbiology
• Volume: 49
• Issue: 2
• Pages: 319-329
• Publication date: 2003-07-01
• DOI: 10.1046/j.1365-2958.2003.03566.x
• EISSN: 1365-2958
• ISSN: 0950-382X
• Language: English
• Keywords: Cell Line; Animals; Phenotype; Oocysts; Laminin; Sequence Alignment; Two-Hybrid System Techniques; Protozoan Proteins; Female; Anopheles; Malaria; Molecular Sequence Data; Digestive System; Amino Acid Sequence; Animals, Genetically Modified; Plasmodium berghei; Insect Proteins; Male