Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype.

Journal article

BACKGROUND: A North American genome-wide single nucleotide polymorphism (SNP) association study identified IL23R as a novel inflammatory bowel disease (IBD) susceptibility gene. Association was reported with multiple risk variants in the centromeric portion of IL23R in 3 large independent cohorts. The aims of this study were to replicate the association of IL23R with Crohn's disease (CD), examine subphenotype relationships, and look for evidence of epistasis with the known CD susceptibility ...

Expand abstract

Authors: Cummings, JR; Ahmad, T; Geremia, A; Beckly, J; Cooney, R

• Publication status: Published
• Journal: Inflammatory bowel diseases
• Volume: 13
• Issue: 9
• Pages: 1063-1068
• Publication date: 2007-09-01
• DOI: 10.1002/ibd.20180
• EISSN: 1536-4844
• ISSN: 1078-0998
• Language: English
• Keywords: Receptors, Interleukin; Inflammation; Gene Expression Regulation; Humans; Adult; Genetic Predisposition to Disease; Male; Female; Phenotype; Epistasis, Genetic; Polymorphism, Single Nucleotide; Colitis, Ulcerative; Inflammatory Bowel Diseases; Centromere; Middle Aged; Adolescent; Crohn Disease