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Clinical grade OK432-activated dendritic cells: in vitro characterization and tracking during intralymphatic delivery.

Abstract:

Dendritic cells (DC) are under intense preclinical and early clinical evaluation for the immunotherapy of cancer. However, the optimal culture conditions and route of delivery for DC vaccination have not been established. Here we describe the first human application of DC matured with the bacterial agent OK432 (OK-DC), using a short-term serum-free culture protocol, which generates mature DC from CD14+ precursors after 5 days. These cells were prepared within the framework of a National Blood...

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Publication status:
Published

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Authors


Merrick, A More by this author
Lubenko, A More by this author
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Journal:
Journal of immunotherapy (Hagerstown, Md. : 1997)
Volume:
32
Issue:
1
Pages:
66-78
Publication date:
2009-01-05
DOI:
EISSN:
1537-4513
ISSN:
1524-9557
URN:
uuid:e0030ddd-e59e-4670-879d-47f17b3dc101
Source identifiers:
348760
Local pid:
pubs:348760

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