Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart.

Journal article

Heart failure patients have abnormal cardiac high energy phosphate metabolism, the explanation for which is unknown. Patients with heart failure also have elevated plasma free fatty acid (FFA) concentrations. Elevated FFA levels are associated with increased cardiac mitochondrial uncoupling proteins (UCPs), which, in turn, are associated with decreased mitochondrial respiratory coupling and low cardiac efficiency. Here, we determined whether increased mitochondrial UCP levels contribute to de...

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Authors: Murray, A; Cole, M; Lygate, C; Carr, C; Stuckey, D

• Publication status: Published
• Journal: Journal of molecular and cellular cardiology
• Volume: 44
• Issue: 4
• Pages: 694-700
• Publication date: 2008-04-01
• DOI: 10.1016/j.yjmcc.2008.01.008
• EISSN: 1095-8584
• ISSN: 0022-2828
• Language: English
• Keywords: Coronary Circulation; Male; Rats; Adenosine Diphosphate; Perfusion; Oxygen Consumption; Mitochondria, Heart; Cell Respiration; Rats, Wistar; Citrate (si)-Synthase; Myocardial Infarction; Animals; Mitochondrial Proteins; Cardiac Output; Heart Failure; Ion Channels