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Journal article

Strategies for long-term expression of transgenes in the respiratory epithelium.

Abstract:

Lung gene therapy is being developed to treat acute and chronic airway diseases, and many viral and non-viral gene transfer vectors have been evaluated in the airway epithelium lining the nose and lung. Stem cells have not been clearly defined in the airways and, currently, it is only possible to target progenitor cells to proliferate and repair the epithelium after inducing epithelial damage. However, the majority of airway epithelial cells are slowly dividing or terminally differentiated, t...

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Authors


Bazzani, RP More by this author
Journal:
Current opinion in molecular therapeutics
Volume:
12
Issue:
4
Pages:
386-393
Publication date:
2010-08-05
EISSN:
2040-3445
ISSN:
1464-8431
URN:
uuid:dff58ca0-1b2d-4649-9e37-743249714bc2
Source identifiers:
246606
Local pid:
pubs:246606

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