Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network.

Journal article

OBJECTIVE: Wnt signaling inhibits adipogenesis, but its regulation, physiological relevance, and molecular effectors are poorly understood. Here, we identify the Wnt modulator Dapper1/Frodo1 (Dact1) as a new preadipocyte gene involved in the regulation of murine and human adipogenesis. RESEARCH DESIGN AND METHODS: Changes in Dact1 expression were investigated in three in vitro models of adipogenesis. In vitro gain- and loss-of-function studies were used to investigate the mechanism of Dact1 a...

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Authors: Lagathu, C; Christodoulides, C; Virtue, S; Cawthorn, W; Franzin, C

• Publication status: Published
• Journal: Diabetes
• Volume: 58
• Issue: 3
• Pages: 609-619
• Publication date: 2009-03-01
• DOI: 10.2337/db08-1180
• EISSN: 1939-327X
• ISSN: 0012-1797
• Language: English
• Keywords: Wnt Proteins; RNA, Messenger; Nerve Tissue Proteins; Humans; Gene Expression Regulation; TCF Transcription Factors; Genes, Reporter; Reverse Transcriptase Polymerase Chain Reaction; Adipocytes; Mice, Inbred C57BL; Adaptor Proteins, Signal Transducing; beta Catenin; Nuclear Proteins; Animals; 3T3-L1 Cells; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Differentiation; Adipose Tissue; Intracellular Signaling Peptides and Proteins; Oligonucleotide Array Sequence Analysis; Mice