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Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network.

Abstract:

OBJECTIVE: Wnt signaling inhibits adipogenesis, but its regulation, physiological relevance, and molecular effectors are poorly understood. Here, we identify the Wnt modulator Dapper1/Frodo1 (Dact1) as a new preadipocyte gene involved in the regulation of murine and human adipogenesis. RESEARCH DESIGN AND METHODS: Changes in Dact1 expression were investigated in three in vitro models of adipogenesis. In vitro gain- and loss-of-function studies were used to investigate the mechanism of Dact1 a...

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Publication status:
Published

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Publisher copy:
10.2337/db08-1180

Authors


Lagathu, C More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Cawthorn, WP More by this author
Franzin, C More by this author
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Journal:
Diabetes
Volume:
58
Issue:
3
Pages:
609-619
Publication date:
2009-03-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:dfe30de6-7dc8-44a3-a09f-5db37245c48a
Source identifiers:
149978
Local pid:
pubs:149978

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