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Killer cell lectin-like receptor G1 inhibits NK cell function through activation of Adenosine 5'-monophosphate-activated protein kinase

Abstract:

NK cells are the first line of defense against infected and transformed cells. Defective NK cell activity was shown to increase susceptibility for viral infections and reduce tumor immune-surveillance. With age, the incidence of infectious diseases and malignancy rises dramatically, suggesting that impaired NK cell function might contribute to disease in these individuals. We found an increased frequency of NK cells with high expression of the inhibitory killer cell lectin-like receptor G1 (K...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4049/jimmunol.1600590

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
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Funding agency for:
Lanna, A
Grant:
AZR00630
Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
197
Issue:
7
Pages:
2891-2899
Publication date:
2016-10-01
Acceptance date:
2016-08-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Pmid:
27566818
Source identifiers:
641624
Language:
English
Keywords:
Pubs id:
pubs:641624
UUID:
uuid:dfde71e0-1027-4fe1-b8a0-f746df2549d3
Local pid:
pubs:641624
Deposit date:
2016-11-02

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