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Killer cell lectin-like receptor G1 inhibits NK cell function through activation of Adenosine 5'-monophosphate-activated protein kinase

Abstract:

NK cells are the first line of defense against infected and transformed cells. Defective NK cell activity was shown to increase susceptibility for viral infections and reduce tumor immune-surveillance. With age, the incidence of infectious diseases and malignancy rises dramatically, suggesting that impaired NK cell function might contribute to disease in these individuals. We found an increased frequency of NK cells with high expression of the inhibitory killer cell lectin-like receptor G1 (K...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4049/jimmunol.1600590

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Department:
Oxford, MSD, NDORMS, KIR
Role:
Author
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Funding agency for:
Lanna, A
Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
197
Issue:
7
Pages:
2891-2899
Publication date:
2016-10-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Pubs id:
pubs:641624
URN:
uri:dfde71e0-1027-4fe1-b8a0-f746df2549d3
UUID:
uuid:dfde71e0-1027-4fe1-b8a0-f746df2549d3
Local pid:
pubs:641624
Paper number:
7
Language:
English
Keywords:

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