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Cyclin D-1 protein over-expression is not associated with gene amplification in benign and atypical apocrine lesions of the breast

Abstract:

Cyclin D-1 protein over-expression and/or gene amplification have been shown to be frequent events in subsets of breast carcinomas. Cyclin D-1 is generally considered as a weak oncogene, and its over-expression has been shown to occur in occasional benign breast lesions. In a previous series, we have shown that cyclin D-1 was over-expressed in subsets of apocrine metaplasia (APM) and apocrine adenosis (AA) of the breast and that such over-expression was mostly associated with a significant in...

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Publisher copy:
10.1016/j.prp.2010.06.003

Authors


Selim, AGA More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
Pathology Research and Practice
Volume:
207
Issue:
2
Pages:
75-78
Publication date:
2011-02-15
DOI:
EISSN:
1618-0631
ISSN:
0344-0338
URN:
uuid:dfd7494f-2248-482f-ae29-92130fce2083
Source identifiers:
120503
Local pid:
pubs:120503
Language:
English
Keywords:

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