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Hedging against antiviral resistance during the next influenza pandemic using small stockpiles of an alternative chemotherapy.

Abstract:

BACKGROUND: The effectiveness of single-drug antiviral interventions to reduce morbidity and mortality during the next influenza pandemic will be substantially weakened if transmissible strains emerge which are resistant to the stockpiled antiviral drugs. We developed a mathematical model to test the hypothesis that a small stockpile of a secondary antiviral drug could be used to mitigate the adverse consequences of the emergence of resistant strains. METHODS AND FINDINGS: We used a multistr...

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Authors


Lipsitch, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Journal:
PLoS medicine
Volume:
6
Issue:
5
Pages:
e1000085
Publication date:
2009-05-05
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
URN:
uuid:dfd13927-2c18-4131-8e4c-432aafa5ce5f
Source identifiers:
223884
Local pid:
pubs:223884

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