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Ibotenic acid induced demyelination in the central nervous system: a consequence of a local inflammatory response.

Abstract:

We examined the effects of injections of ibotenic acid into the medial septum (MS), dorsal lateral geniculate nucleus (dLGN), caudate-putamen (CP) or fornix-fimbria (FF) on fibres close to the injection site. Injections into the MS and dLGN resulted in demyelination. The area of demyelination correlated with the area of maximal gliosis. The major cell type in the area of gliosis were cells of haemopoietic origin, as revealed by using monoclonal antibodies (Mabs). Demyelination was not observe...

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Publication status:
Published

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Authors


Coffey, PJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
Neuroscience letters
Volume:
84
Issue:
2
Pages:
178-184
Publication date:
1988-01-05
DOI:
EISSN:
1872-7972
ISSN:
0304-3940
URN:
uuid:dfcc79f3-0560-4bb0-bcfd-5326edf85ddc
Source identifiers:
5358
Local pid:
pubs:5358

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