Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD.

Journal article

BACKGROUND: Asthma and COPD are characterized by airway dysfunction and inflammation. Neutrophilic airway inflammation is a common feature of COPD and is recognized in asthma, particularly in severe disease. The T helper (Th) 17 cytokines IL-17A and IL-17F have been implicated in the development of neutrophilic airway inflammation, but their expression in asthma and COPD is uncertain. METHODS: We assessed IL-17A and IL-17F expression in the bronchial submucosa from 30 subjects with asthma, 1...

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Authors: Doe, C; Bafadhel, M; Siddiqui, S; Desai, D; Mistry, V

• Journal: Chest
• Volume: 138
• Issue: 5
• Pages: 1140-1147
• Publication date: 2010-11-01
• DOI: 10.1378/chest.09-3058
• EISSN: 1931-3543
• ISSN: 0012-3692
• Language: English
• Keywords: Asthma; Female; Spirometry; Th17 Cells; Male; Sputum; Severity of Illness Index; Respiratory Mucosa; Pulmonary Disease, Chronic Obstructive; Interleukin-17; Biopsy; Enzyme-Linked Immunosorbent Assay; Middle Aged; Humans; Bronchi